Valproic acid (as semisodium valproate)
Manic episodes associated with bipolar disorder.
MHRA Drug Safety Update - Medicines related to valproate: risk of abnormal pregnancy outcomes
MHRA Drug Safety Update - Valproate medicines (Epilim▼, Depakote▼): contraindicated in women and girls of childbearing potential unless conditions of Pregnancy Prevention Programme are met
LSCMMG is adopting the local decision made prior to April 2013
Update March 2016 — there is a risk of abnormal pregnancy outcomes following maternal use. See DoH Drug Safety Alert for more information.
The colour classification was determined as part of the collaborative work between LCFT and medicines Management leads. Local pathways and patient safety were taken into consideration.
Amber level 0
Reason for decision:
Suitable for GP prescribing following recommendation/initiation by specialist